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Zinc Plus


Highly Bioavailable Zinc Ascorbate and Bioflavonoid Compounds*

Blend of Zinc, Vitamin C, and Organic Citrus Bioflavonoids to support healthy immune system function, boost antioxidant status, and decrease inflammation*

Zinc Plus is a highly bioavailable formulation of zinc ascorbate and organic citrus bioflavonoids. This non-GMO product provides 12 mg of zinc per capsule, as well as 64 mg of vitamin C and 45 mg of bioflavonoids. This formula supports immune function and assists with the repair and maintenance of healthy body tissues.*

How Does Zinc Plus Work?

Zinc Plus is formulated with high-quality nutrients and plant extracts to help improve immune function and optimize tissue health in the face of oxidative stress.*

Zinc Plus Main Label Data Sheet

Supplementation with Zinc Plus:

      What the Research and Clinical Use Shows:

      Zinc Ascorbate:

      Zinc is an essential mineral found in animal foods such as eggs, meat, and seafood. This mineral is crucial for thousands of biochemical pathways in the body. Most notably, zinc is imperative for modulating inflammation and immune function.

      Zinc is the key to proper immune system development and function. Zinc is a cofactor in the development and production of T-lymphocyte cells, which are required for a healthy immune response.1 Zinc is also needed to produce ROS (reactive oxygen species), which help the immune system defend the body from dangerous pathogens.1 A zinc deficiency causes severe immune dysfunction.1

      Zinc is also required to defend the body from degenerative diseases such as rheumatoid arthritis, diabetes mellitus, and atherosclerosis.1 Frank deficiency of zinc in the developed world is most commonly seen in the elderly (up to 30%) and contributes to higher levels of degenerative disease in these populations.1 Lifestyle factors, including intake of foods high in phytates and alcohol consumption, can also reduce zinc levels in individuals of all ages.2

      Zinc deficiency is also known to impair spermatogenesis, reduce testosterone output, slow growth, and retard wound healing.2,3 Additionally, zinc is also required for proper red blood cell formation.1

      Zinc deficiency can lead to an increase in the incidence of cancers, allergies, and mental illnesses, such as depression and schizophrenia.1

      Vitamin C: 

      Vitamin C is required for the healthy structure and function of the body. Several large-scale prospective cohort studies have supported a correlation between vitamin C status and a lower risk of mortality and cardiovascular diseases.4,5¬†Vitamin C is required for the formation of bones, muscles, and cartilage.6 Additionally, vitamin C is an important antioxidant, a modulator of the immune system, and is needed for neurotransmitter synthesis.6 Vitamin C is considered an ‚Äúimmunostimulant‚ÄĚ because it encourages immune cell activity against pathogens.6 Vitamin C also inhibits histamine secretion by mast cells and lowers blood histamine levels, thereby improving allergy symptoms.7

      Organic Citrus Bioflavonoid Complex From Lemon (Citrus limon), Orange (Citrus sinensis), and Tangerine (Citrus reticulata) Fruit: 

      Flavonoids are polyphenolic plant chemicals found throughout the plant kingdom and offer a variety of physiological benefits. Citrus bioflavonoids are isolated specifically from the Citrus genus.

      Citrus bioflavonoids are powerful compounds with antimicrobial as well as antioxidant effects.8 One citrus bioflavonoid, hesperidin, has been shown to reduce circulating levels of inflammatory biomarkers and pro-atherogenic compounds in the human body.9 Studies have demonstrated repeatedly that bioflavonoids, as a class, decrease circulating markers of inflammation and protect human cells from oxidation and even from developing certain cancers and neurodegenerative conditions.10-12

      When it comes to the immune system, citrus bioflavonoids are known to exert beneficial effects there as well. In a clinical study of patients with hepatitis C virus (HCV), orange juice as a source of bioflavonoids was shown to help the body defend against many of the detrimental effects of this chronic viral infection.13

      Zinc Plus Supplement Facts & Caution Data Sheet

      References:

      1 Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017;9(12):1286. doi:10.3390/nu9121286

      2 Saper RB, Rash R. Zinc: an essential micronutrient. Am Fam Physician. 2009;79(9):768-772.

      3 Kilic M, Baltaci AK, Gunay M, et al. The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc. Neuro Endocrinol Lett. 2006;27(1-2):247-252.

      4 McRae MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. J Chiropr Med. 2008;7(2):48-58. doi:10.1016/j.jcme.2008.01.002

      5 Pocobelli G, Peters U, Kristal AR, et al. Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol. 2009;170(4):472-483. doi:10.1093/aje/kwp167

      6 Sorice A, Guerriero E, Capone F, et al. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Rev Med Chem. 2014;14(5):444-452. doi:10.2174/1389557514666140428112602

      7 Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev. 2006;11(3):196-207.

      8 Iranshahi M, Rezaee R, Parhiz H, et al. Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin. Life Sci. 2015;137:125-132. doi:10.1016/j.lfs.2015.07.014

      9 Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011;96(5):E782-E792. doi:10.1210/jc.2010-2879

      10 Parhiz H, Roohbakhsh A, Soltani F, et al. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2015;29(3):323-331. doi:10.1002/ptr.5256

      11 Spencer JP, Vafeiadou K, Williams RJ, et al. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2012;33(1):83-97. doi:10.1016/j.mam.2011.10.016

      12 Alam MA, Subhan N, Rahman MM, et al. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr. 2014;5(4):404-417. doi:10.3945/an.113.005603

      13 Gonçalves D, Lima C, Ferreira P, et al. Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy. Food Nutr Res. 2017;61(1):1296675. doi:10.1080/16546628.2017.1296675