Summer is an opportune time to focus on health – the weather tends to be pleasant, which makes many people naturally feel like being more active and vigorous. Since June is also Men’s Health Month, let’s discuss a few nutrients that could be beneficial for men during a fun and healthy summer. According to the research, supplementing with zinc, vitamin C, and citrus bioflavonoids together could support optimal testosterone levels, recovery from injuries, and athletic performance.*
Zinc
Zinc is the second-most abundant trace element in the human body; and plays a crucial role in many metabolic processes, including energy metabolism, immune function, hormone production, and muscle contraction.1-3 Zinc does not readily accumulate in the body; therefore, it is essential to consume this mineral daily from foods and/or supplementation.2,4 It is recommended that most adults consume at least 14mg of zinc per day.5
Zinc is a component of over 300 crucial enzymes, so a zinc deficiency could significantly impair health.6 Roughly two billion people worldwide are affected by suboptimal zinc status, and a severe zinc deficiency may contribute to multiple disorders, including immune abnormalities, abnormal hormone levels, and skin concerns. Zinc deficiency is also associated with the development of cardiovascular diseases and anemia. Since approximately 60% of all zinc in the body is in muscle and only 0.1% is in the blood plasma, the blood zinc level is not a reliable marker of zinc status.3 Therefore, diagnosing a zinc deficiency can be challenging.
In men, a zinc deficiency may negatively impact health in many ways. A low zinc level can affect testosterone due to zinc’s role in hormone metabolism and its effect on steroid hormone receptors.7 The pituitary in the brain produces a hormone called luteinizing hormone (LH) that then stimulates testosterone production in the Leydig cells in the male reproductive system. Zinc is required for both the synthesis and the secretion of LH, so testosterone production is zinc-dependent.4,5 And, several studies have shown a zinc deficiency correlates with a lower testosterone level in the blood. Research has also demonstrated the restoration of normal testosterone levels after supplementation with zinc.8 When evaluating the overall effect of a hormone, though, one must consider the amount of the hormone present plus the number of receptors, or binding sites, since the receptors allow the hormone to exert its effects in the body. An animal study demonstrated that zinc deficiency decreases the number of testosterone binding sites, which then causes an overall reduction in the impact of the testosterone.9
It is fascinating to note competitive athletes appear to be at a greater risk for zinc deficiency than the general population. One study that examined the effect of zinc supplementation on testosterone concentrations in healthy young adults before and after exhaustive exercise reported that zinc supplementation increased testosterone levels when compared to pre-supplementation levels.5 Intense exercise may reduce the red blood cell (RBC) concentrations of zinc, which could then impair athletic performance. According to a study by Maynar et al., the swimmers with the highest degree of training had the lowest RBC zinc levels.2
Insufficient dietary zinc intake may also decrease exercise performance by affecting glucose uptake, glycogen synthesis, strength, endurance, aerobic power, insulin signaling, protein synthesis, and muscle repair mechanisms.1,3-7,10 Taken together, depletion of zinc in the body could negatively impact athletic performance to a significant extent.1 For this reason, active individuals could consider monitoring the zinc level in their red blood cells and supplementing with zinc to avoid the detrimental effects of a zinc deficiency on athletic performance.2
Zinc also plays a significant role in wound healing, and injuries can be common when engaging in physical activity during the summer. Studies dating back to the 1970s have shown the importance of an optimal zinc status for wound healing in patients with burn injuries and those recovering from surgery. Zinc is especially important in the skin, and approximately 5% of the zinc in the body is in the skin. Even a mild zinc deficiency is associated with roughened skin and impaired wound healing.11 Zinc helps coordinate every phase of the wound healing process. Specifically, zinc affects membrane repair, oxidative stress, inflammation, immune defense, tissue regeneration, blood vessel regeneration, and scar formation.11,12 Animal studies of the wound healing process have shown that within the first 24 hours after injury, there is a 15% to 20% increase in zinc levels near the wound, which then surges up to 30% as wound healing continues.12
Vitamin C
Vitamin C is an essential vitamin that must be consumed daily. In humans, vitamin C is abundant in the endocrine system and is necessary to regulate adrenal and gonadal steroid hormone production, including testosterone production. There is also a high concentration of vitamin C in the pituitary gland in the brain, and vitamin C appears to play a significant role in the secretion of several pituitary hormones, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Since testosterone production is regulated by LH, adequate vitamin C intake is necessary for optimal testosterone levels. One animal study confirmed administration of vitamin C significantly increased testosterone production by over 400% in three weeks.13 And, several additional animal studies confirm the administration of vitamin C increases testosterone production in general.14-16 Research also confirms Vitamin C protects against the effects of toxic substances that could impact the testosterone level, including alcohol, medications, and toxic metals.17-24 And, like zinc, vitamin C is required for optimal wound healing. Since vitamin C promotes the synthesis of collagen and a healthy inflammatory response, it supports the healing of cuts, scrapes, sprains, strains, and other types of summertime injuries.25-29
Citrus Bioflavonoids
Polyphenols are compounds naturally present in plants and include bioflavonoids derived from fruits such as citrus, pomegranates, cherries, and berries. Recent studies have shown polyphenols have anti-inflammatory and antioxidant effects that could offer an effective strategy to enhance muscle strength and improve muscle recovery after exercise.30,31 Nutritional supplementation is commonly used by athletes – should they consider adding bioflavonoids to a supplementation protocol?
Let’s look at the research!
A clinical trial that assessed whether supplementation with a citrus bioflavonoid complex for up to 8 weeks improved anaerobic exercise capacity concluded YES – daily supplementation with a citrus bioflavonoid complex significantly improved anaerobic capacity and peak power during high-intensity exercise in moderately trained individuals. Another clinical study showed polyphenols increased maximal power output, average power, and total power output during high-intensity exercise without inducing more fatigue.30 Moreover, the administration of citrus bioflavonoids improved vascular function by reducing inflammation and stimulating nitric oxide production. Increased nitric oxide production is associated with the dilation of blood vessels, which then causes a reduction in blood pressure and an increase in blood flow to active muscles. The increased blood flow removes fatigue-related metabolites and delivers critical nutrients and oxygen to the muscles.30,31 Overall, studies have determined bioflavonoids increase average power by 2.3% to 5%, maximum speed by 3.2%, peak power by 3.7%, and total energy by 2.6% without increasing the maximum heart rate (HR).30 Furthermore, bioflavonoids may exert other intracellular effects that support mitochondrial function to maintain a high energy level. Research has also shown polyphenols induce the biogenesis of new mitochondria, which then produce additional energy for further gains.31 According to the latest research, citrus bioflavonoids could be included in a supplement protocol to maximize athletic performance capacity.*
In conclusion, zinc, vitamin C, and citrus bioflavonoids are supplements all men could consider incorporating into their daily routine this summer. Research confirms these nutrients support optimal testosterone levels, recovery from summertime injuries, and improved athletic performance, which will help everyone have a healthy, active, and fun summer!*
Zinc, Vitamin C, and Citrus Bioflavonoid Complex are available as a synergistic blend in Zinc PlusTM from Interplexus.*
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
You May Also Enjoy
DO YOU FEEL LIKE YOUR VITALITY AND IMMUNE HEALTH COULD USE A BOOST?
While many of us know that daily supplementation with probiotics supports health, research is now beginning to teach us about the fascinating world of POSTbiotics!
ARE STRESS AND ANXIETY DRAINING YOUR ENERGY? TRY INTERPLEXUS' B-KALMPLEXUS
Introducing InterPlexus' new B-Complex offering, B-KalmPlexus™. Interplexus B-KalmPlexus is a unique formulation that contains essential B vitamins plus synergistic nutrients and organic Ashwagandha to support a healthy stress response and sustained cellular energy levels.*
DO YOU NEED SUPPLEMENTS? AN EVIDENCE-BASED DISCUSSION
Think you don’t need supplements? Think again! You may want to reconsider your thoughts about supplements to improve your health and well-being since your body requires a certain amount of each of the essential nutrients daily to function optimally!
References:
-
Shaw KA, Zello GA, Rodgers CD, et al. Benefits of a plant-based diet and considerations for the athlete. Eur J Appl Physiol. 2022;122(5):1163-1178.
-
Maynar M, Grijota FJ, Siquier-Coll J, et al. Erythrocyte concentrations of chromium, copper, manganese, molybdenum, selenium and zinc in subjects with different physical training levels [published correction appears in J Int Soc Sports Nutr. 2021;18(1):30]. J Int Soc Sports Nutr. 2020;17(1):35. doi:10.1186/s12970-020-00367-4
-
Hernández-Camacho JD, Vicente-García C, Parsons DS, et al. Zinc at the crossroads of exercise and proteostasis. Redox Biol. 2020;35:101529.
-
Fallah A, Mohammad-Hasani A, Colagar AH. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization. J Reprod Infertil. 2018;19(2):69-81.
-
Zamir A, Ben-Zeev T, Hoffman JR. Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations. Nutrients. 2021;13(10):3375. doi:10.3390/nu13103375
-
Williams MH. Dietary supplements and sports performance: minerals. J Int Soc Sports Nutr. 2005;2(1):43-49.
-
Kerksick CM, Wilborn CD, Roberts MD, et al. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018;15(1):38.
-
Prasad AS, Mantzoros CS, Beck FW, et al. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996;12(5):344-8. doi:10.1016/s0899-9007(96)80058-x
-
Om AS, Chung KW. Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. J Nutr. 1996;126(4):842-8. doi:10.1093/jn/126.4.842
-
Chu A, Petocz P, Samman S. Plasma/Serum Zinc Status During Aerobic Exercise Recovery: A Systematic Review and Meta-Analysis. Sports Med. 2017;47(1):127-134.
-
Lin PH, Sermersheim M, Li H, et al. Zinc in Wound Healing Modulation. Nutrients. 2017;10(1):16. doi:10.3390/nu10010016
-
Han B, Fang WH, Zhao S, et al. Zinc sulfide nanoparticles improve skin regeneration. Nanomedicine. 2020;29:102263. doi:10.1016/j.nano.2020.102263
-
Okon UA, Utuk II. Ascorbic acid treatment elevates follicle stimulating hormone and testosterone plasma levels and enhances sperm quality in albino Wistar rats. Niger Med J. 2016;57(1):31-36. doi:10.4103/0300-1652.180570
-
Moghimian M, Soltani M, Abtahi H, et al. Effect of vitamin C on tissue damage and oxidative stress following tunica vaginalis flap coverage after testicular torsion. J Pediatr Surg. 2017;52(10):1651-1655. doi:10.1016/j.jpedsurg.2017.07.001
-
Rizk NI, Rizk MS, Mohamed AS, Naguib YM. Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C. Reprod Biol Endocrinol. 2020;18(1):2. doi:10.1186/s12958-020-0563-y
-
Sönmez M, Türk G, Yüce A. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology. 2005;63(7):2063-72. doi:10.1016/j.theriogenology.2004.10.003
-
Ayinde OC, Ogunnowo S, Ogedegbe RA. Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharmacol Toxicol. 2012;13:17. doi:10.1186/2050-6511-13-17
-
Zeng L, Zhou J, Wang X, et al. Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion. Free Radic Biol Med. 2021;176:176-188. doi:10.1016/j.freeradbiomed.2021.09.028
-
Sen Gupta R, Sen Gupta E, Dhakal BK, et al. Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells. 2004;17(1):132-9.
-
Mouro VGS, Martins ALP, Silva J, et al. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxid Med Cell Longev. 2019;2019:3429635. doi:10.1155/2019/3429635
-
Min Y, Sun T, Niu Z, et al. Vitamin C and vitamin E supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters. Anim Reprod Sci. 2016;171:1-6. doi:10.1016/j.anireprosci.2016.04.005
-
Murugesan P, Muthusamy T, Balasubramanian K, et al. Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)--induced oxidative damage in Leydig cells. Free Radic Res. 2005;39(11):1259-72. doi:10.1080/10715760500308154
-
Harikrishnan R, Abhilash PA, Syam Das S, et al. Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs. Br J Nutr. 2013;110(4):689-98. doi:10.1017/S0007114512005739
-
Babcock MC, DuBose LE, Witten TL, et al. Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone. J Clin Endocrinol Metab. 2022;107(2):e500-e514. doi:10.1210/clinem/dgab715
-
Palmieri B, Vadalà M, Laurino C. Nutrition in wound healing: investigation of the molecular mechanisms, a narrative review. J Wound Care. 2019;28(10):683-693. doi:10.12968/jowc.2019.28.10.683
-
Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866. doi:10.3390/nu9080866
-
Martel M, Laumonerie P, Girard M, et al. Does vitamin C supplementation improve rotator cuff healing? A preliminary study. Eur J Orthop Surg Traumatol. 2022;32(1):63-70. doi:10.1007/s00590-021-02926-0
-
Lui PPY, Zhang X, Yao S, et al. Roles of Oxidative Stress in Acute Tendon Injury and Degenerative Tendinopathy-A Target for Intervention. Int J Mol Sci. 2022;23(7):3571. doi:10.3390/ijms23073571
-
Heaton LE, Davis JK, Rawson ES, et al. Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview. Sports Med. 2017;47(11):2201-2218. doi:10.1007/s40279-017-0759-2
-
van Iersel LE, Stevens YR, Conchillo JM, et al. The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial. J Int Soc Sports Nutr. 2021;18(1):2. doi:10.1186/s12970-020-00399-w
-
Overdevest E, Wouters JA, Wolfs KHM, et al. Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes. J Sports Sci Med. 2018;17(1):24-30.
Leave a comment