Bioavailable Calcium Compounds* (Calcium Citrate & Bisglycinate)
Supports healthy bone development and maintenance, muscle function (including heart), and nervous system function.*
Calcium citrate and calcium bisglycinate are fully-reacted, organically-bound calcium salts known to have excellent bioavailability.
Why "Non-GMO" is important:
InterPlexus is dedicated to providing the highest quality supplements available. Quality starts with the raw materials used to make our products. We ensure that no genetically modified ingredients (GMOs) are used in manufacturing this product.
Why "Minimal Excipients" is important:
Excipients or “other ingredients” in supplements are used as a part of the manufacturing process and are not considered nutritionally relevant. Some examples of excipients include bulking agents, coatings, colors, and flavors. This product is intentionally formulated with only minimal and natural excipients because InterPlexus is committed to producing supplements that are the safest and most beneficial for our consumers.
Supplementation with Calcium2:
- Supports healthy bone development & maintenance*
- Supports optimal muscle function*
- Supports the heart & blood pressure*
- Supports nerve function*
- Contributes to a healthy body weight*
- Contributes to a healthy menstrual cycle*
How Does Calcium2 Work:
Calcium2 is formulated with two highly bioavailable calcium salts that support healthy cardiovascular, musculoskeletal, and nervous system function.* Many individuals do not consume the recommended daily intake of calcium from food or are unable to absorb the calcium they are consuming. Because calcium is an essential nutrient, calcium supplementation is often a crucial addition to a healthy lifestyle.
Importance of Formulation:
Many calcium supplements on the market use calcium carbonate as their main source of calcium, which is an inexpensive form of calcium that is often poorly absorbed. Calcium citrate is a preferred form for a calcium supplement because absorption is not affected by the presence or absence of stomach acid. Therefore, calcium citrate can be taken with or without meals. InterPlexus takes calcium supplementation to the next level with the addition of calcium bisglycinate, an amino acid chelate of calcium. Chelated forms of minerals provide superior bioavailability and absorption.*
What the Research Shows:
Calcium, the most abundant mineral in the body, plays many crucial roles in human physiology. Calcium is required for the regulation of blood vessel contraction and dilation, the contraction of muscles, the conduction of nerve signals, and hormone secretion.1
Calcium is also required for the growth and maintenance of healthy bones. Calcium-deficient diets may result in poor bone formation for infants and children and the loss of bone mass later in life. Throughout the lifespan, decreased serum calcium levels may lead to net resorption of bone and loss of bone mass to satisfy daily calcium needs.1 Calcium supplementation in older adults slows the progression of osteoporosis and reduces the risk of fractures.2 The American College of Rheumatology recommends older adults receiving corticosteroid treatments are in particular need of calcium supplementation.3
Calcium status affects cardiovascular health. Studies suggest calcium reduces blood pressure.4 Research on calcium supplementation shows a decreased risk or severity of preeclampsia for pregnant women and therefore decreased risk of related sequelae, including preterm labor.5 Additionally, calcium supplementation may decrease LDL and increase HDL cholesterol. In a study where subjects with mild to moderate hypercholesterolemia took the RDA of calcium and made dietary changes, statistically significant decreases in LDL and an increase in HDL occurred.6
There has been a concern in research regarding the risk of cardiovascular disease and calcium supplementation. Recently a meta-analysis of the existing research on calcium supplementation in elderly women found no increased risk of cardiovascular events in those taking calcium supplements. Experts continue to recommend that older women supplement with calcium as they are unlikely to reach their calcium goals through diet alone.7
Calcium may be associated with decreased risk of recurrence of colon cancer. A meta-analysis of three randomized, controlled trials showed a decreased colorectal cancer recurrence rate with calcium supplementation; however, more research is warranted.8 A Cochrane review found calcium supplementation prevented the recurrence of colon adenomas, but the review did not determine if there is yet enough evidence to recommend calcium as the standard of care for cancer prevention.9
Calcium may also help improve PMS symptoms.10 Women consuming amounts of calcium greater than the RDA showed fewer PMS-related symptoms such as low mood, water retention, and pain than those taking less calcium. Women who ate, on average, 1283 mg of calcium per day (from food) had a 30% less chance of exhibiting PMS symptoms than those who ate, on average, 529 mg per day.11
Calcium may help regulate healthy body weight. A meta-analysis of several prospective studies showed a correlation between calcium intake and body mass index (BMI) through a variety of suggested mechanisms.12 Mouse models suggest low calcium intake is associated with increased fat production in body tissues.13 Higher calcium diets are thought to increase the amount of fecal fat excreted and decrease the gastrointestinal absorption of fats.14
1 Erdman JW, Macdonald I, Zeisel SH, Weaver CM. Calcium. In: Present Knowledge in Nutrition. International Life Sciences Institute; 2012:434-446.
2 Prince RL, Devine A, Dhaliwal SS, et al. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med. 2006;166(8):869-875. doi:10.1001/archinte.166.8.869
3 Grossman JM, Gordon R, Ranganath VK, et al. American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis [published correction appears in Arthritis Care Res (Hoboken). 2012 Mar;64(3):464]. Arthritis Care Res (Hoboken). 2010;62(11):1515-1526. doi:10.1002/acr.20295
4 Dickinson HO, Nicolson DJ, Cook JV, et al. Calcium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev. 2006;(2):CD004639. doi:10.1002/14651858.CD004639.pub2
5 Villar J, Abdel-Aleem H, Merialdi M, et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol. 2006;194(3):639-649. doi:10.1016/j.ajog.2006.01.068
6 Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992;152(12):2441-2444.
7 Lewis JR, Radavelli-Bagatini S, Rejnmark L, et al. The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials. J Bone Miner Res. 2015;30(1):165-175. doi:10.1002/jbmr.2311
8 Carroll C, Cooper K, Papaioannou D, et al. Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis. Clin Ther. 2010;32(5):789-803. doi:10.1016/j.clinthera.2010.04.024
9 Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2008;2008(1):CD003548. doi:10.1002/14651858.CD003548.pub4
10 Thys-Jacobs S, Starkey P, Bernstein D, et al. Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms. Premenstrual Syndrome Study Group. Am J Obstet Gynecol. 1998;179(2):444-452. doi:10.1016/s0002-9378(98)70377-1
11 Bertone-Johnson ER, Hankinson SE, Bendich A, et al. Calcium and vitamin D intake and risk of incident premenstrual syndrome. Arch Intern Med. 2005;165(11):1246-1252. doi:10.1001/archinte.165.11.1246
12 Dougkas A, Reynolds CK, Givens ID, et al. Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms. Nutr Res Rev. 2011;24(1):72-95. doi:10.1017/S095442241000034X
13 Gonzalez JT, Rumbold PL, Stevenson EJ. Effect of calcium intake on fat oxidation in adults: a meta-analysis of randomized, controlled trials. Obes Rev. 2012;13(10):848-857. doi:10.1111/j.1467-789X.2012.01013.x
14 Christensen R, Lorenzen JK, Svith CR, et al. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obes Rev. 2009;10(4):475-486. doi:10.1111/j.1467-789X.2009.00599.x