B-KalmPlexus

Essential B Vitamins plus synergistic nutrients to support a healthy stress response and sustained energy levels*

B Vitamins and related nutrients are required for the optimal function of the adrenal glands and for maintaining a healthy response to stress.* Although each of the B vitamins is chemically distinct, they work synergistically to power biochemical functions throughout the body. Most B vitamins are not stored in the body; therefore, they must be acquired from the diet or supplemented daily to maintain optimal health.*

B-KalmPlexus combines bioavailable B-1, B-2, B-3, B-5, B-6, folate, B-12, biotin, phosphatidylserine, magnesium, and Ashwagandha in a convenient capsule to support a healthy stress response and sustained energy levels.*

B vitamins play important roles in nearly all physiological processes in the body. Some key supportive roles include the maintenance of muscle tone in the GI tract; functioning of the nervous system; integrity of skin, hair, and nails; production of red blood cells; and optimization of detoxification processes. Furthermore, B vitamins are essential for neurotransmitter synthesis, nerve impulse transmissions, mood support, hormone synthesis, and energy metabolism. This unique formulation also supports cell-to-cell communication and a healthy adrenal response with the inclusion of the critical cell membrane nutrient phosphatidylserine.*

Supplementation with B-KalmPlexus

What the Research and Clinical Use Shows:

Vitamin B1 (Thiamin HCl)

is a water-soluble vitamin that requires magnesium to convert into its active coenzyme form known as thiamin pyrophosphate (TPP). TPP supports the processing of carbohydrates, fat, and protein and is essential for energy production, appropriate adrenal response to ACTH, steroid hormone synthesis (steroidogenesis), cell viability, and proper neuron function.^1,2*

Vitamin B2 (Riboflavin)

participates in the electron transport chain to form ATP, which is the primary energy source in the body. Vitamin B2 is required for the production of 5-methyltetrahydrofolate (MTHF) and the activation of vitamin B6. Riboflavin, like all B vitamins, is crucial for the health and maintenance of many organ systems, including the neurological and cardiovascular systems. Riboflavin is also required for flavoenzymes, including flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are indispensable for the synthesis of cholesterol and related steroid hormones.³*

Vitamin B3 (Nicotinic Acid)

is necessary for adequate cellular metabolism and functions as a vital component in nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD and NADP are critical coenzymes for over 500 enzymatic processes, including glycolysis, pyruvate metabolism, protein and amino acid metabolism, pentose biosynthesis, glycerol metabolism, synthesis of high-energy phosphate bonds, and fatty acid metabolism. Optimal intake of vitamin B3 supports cardiovascular health by modulating healthy lipid and carbohydrate metabolism. A vitamin B3 deficiency can reduce serotonin and melatonin production and dysregulate the circadian rhythm and mood.⁴*

Vitamin B6 (Pyridoxine HCl)

is a water-soluble nutrient required for more than 100 enzymatic reactions in the human body. Pyridoxine is transformed into the active form of B6, known as pyridoxal 5-phosphate (P5P). P5P serves as a coenzyme in amino acid, protein, carbohydrate, and lipid metabolism, in addition to neurotransmitter (GABA and serotonin) synthesis. P5P is also involved in glycogenolysis, gluconeogenesis, and hemoglobin synthesis. Research has shown vitamin B6 by itself and in conjunction with magnesium can reduce anxiety and stress responses in women.⁵*

Folate (Folic Acid)

is essential for the optimal function of the nervous system and many metabolic processes, including the conversion of homocysteine to methionine, the synthesis of neurotransmitters, the production of melatonin, and the synthesis of DNA. In addition, sufficient folate is required for a healthy pregnancy outcome and healthy mood.⁶*

Vitamin B12 (Methylcobalamin)

is required for energy metabolism, homocysteine clearance, and S-adenosylmethionine (SAMe) production. Research implies that vitamin B12 supports a normal circadian rhythm, red blood cell formation, DNA synthesis, a healthy nervous system, a healthy cardiovascular system, and the optimal function of the immune system. Research also suggests that higher B12 levels may contribute to improved sleep quality.⁷*

Biotin

is a water-soluble B vitamin that is an essential co-factor for several metabolic carboxylation reactions, which are required for healthy carbohydrate, fat, and protein metabolism. Research suggests that biotin provides support for optimal glucose and lipid and glucose metabolism, cell signaling, epigenetic regulation, nerve function, and nail strength. Research also shows a higher intake of biotin is associated with a lower prevalence of depression, anxiety, and other stress-induced symptoms.⁸*

Calcium D-Pantothenate (Pantothenic Acid)

commonly known as vitamin B5, is a precursor of acetyl coenzyme A (acetyl CoA), which is a crucial cofactor in various biological processes, such as the metabolism of nucleic acids, lipids, carbohydrates, and proteins. Acetyl CoA is involved in adrenal gland functions, including steroidogenesis and the synthesis of cortisol. Acetyl CoA is also essential in the myelinization and synthesis of the neurotransmitter acetylcholine. Vitamin B5 may also support a reduction in oxidative stress via increased glutathione production.^9,10*

Phosphatidylserine (PS)

is a phospholipid found in all cells, but it is most concentrated in neurons in the brain. PS optimizes cell membrane composition to improve cell signaling, which supports healthy cortisol levels, improves adaptability to stress, enhances mood, calms anxiety, boosts cognitive function, strengthens athletic performance, and speeds recovery after training.¹¹*

Magnesium Citrate Malate

is a highly bioavailable form of magnesium. Magnesium is required for the optimal development and maintenance of bones and teeth; metabolism of carbohydrates, proteins, and fats; formation of cells and tissues; modulation of cytokines; and maintenance of muscle function, including the heart. Research also shows that magnesium supplementation improves glucocorticoid metabolism, sleep quality, metabolic markers (fasting insulin and C-peptide), and blood pressure levels.^12-14*

Ashwagandha (Withania somnifera)

has been a revered botanical medicine in the Ayurvedic system of medicine for hundreds of years. Ashwagandha is an adaptogen that supports physiologic and emotional homeostasis or balance in the mind and body. Research suggests naturally occurring compounds in Ashwagandha may offer cardioprotective, anticancer, antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, anti-depressant, hypoglycemic, antianxiety, anti-sarcopenic, hypolipidemic, and anti-diabetic benefits.¹⁵*

References:

¹Neher R, Milani A. Pyruvate and thiamine pyrophosphate potentiate cyclic nucleotide-induced steroidogenesis in isolated rat adrenocortical cells. J Steroid Biochem. 1983;18(1):1-6. doi:10.1016/0022-4731(83)90321-7.

²Meikle AW, Wittek PJ, Klain GJ. An aberration of glucose metabolism and steroidogenesis in adrenals of thiamin-deficient rats. Endocrinology. 1972;91(5):1206-1212. doi:10.1210/endo-91-5-1206.

³Pinto JT, Cooper AJ. From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D. Adv Nutr. 2014;5(2):144-163. Published 2014 Mar 1. doi:10.3945/an.113.005181.

⁴ Viljoen M, Swanepoel A, Bipath P. Antidepressants may lead to a decrease in niacin and NAD in patients with poor dietary intake. Med Hypotheses. 2015;84(3):178-182. doi:10.1016/j.mehy.2014.12.017.

⁵ McCabe D, Lisy K, Lockwood C, et al. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15(2):402-453. doi:10.11124/JBISRIR-2016-002965.

⁶Bender A, Hagan KE, Kingston N. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017;95:9-18. doi:10.1016/j.jpsychires.2017.07.019.

⁷ Al-Musharaf S, Alabdulaaly A, Bin Mujalli H, et al. Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students. Int J Environ Res Public Health. 2021;18(9):4548. Published 2021 Apr 25. doi:10.3390/ijerph18094548.

⁸Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, et al. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92-98. doi:10.1016/j.jad.2021.03.055.

⁹Fidanaza A, Floridi S, Lenti L. Panthenol and glucocorticoids. Boll Soc Ital Biol Sper. 1981;57(18):1869-1872.

¹⁰ Jaroenporn S, Yamamoto T, Itabashi A, et al. Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. Biol Pharm Bull. 2008;31(6):1205-1208. doi:10.1248/bpb.31.1205.

¹¹Phosphatidylserine. Monograph. Altern Med Rev. 2008;13(3):245-247.

¹²Pickering G, Mazur A, Trousselard M, et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020;12(12):3672. Published 2020 Nov 28. doi:10.3390/nu12123672.

¹³ Sartori SB, Whittle N, Hetzenauer A, et al. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027.

¹⁴ Schutten JC, Joris PJ, Minović I, et al. Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial. Clin Endocrinol (Oxf). 2021;94(2):150-157. doi:10.1111/cen.14350.

¹⁵ Saleem S, Muhammad G, Hussain MA, et al. Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iran J Basic Med Sci. 2020;23(12):1501-1526. doi:10.22038/IJBMS.2020.44254.10378.