Seriphos™

Phosphorylated Serine

Adaptogen and Adrenal Support*

Stress is a common feature of everyday life that can raise cortisol levels and lead to significant health problems. Seriphos was developed to aid in lowering cortisol when cortisol levels are elevated due to acute and chronic stress.*

Seriphos contains key nutrients for stress resiliency.* This original and unique formulation provides phosphorylated serine along with ethanolamine phosphate to promote a more balanced and healthy stress response.* Phosphorylated serine and ethanolamine phosphate serve as metabolic building blocks for the synthesis of phosphatidylserine and phosphatidylethanolamine, cell membrane phospholipids that regulate key aspects of cellular function.

The synergistic formulation of phosphorylated serine and ethanolamine phosphate in Seriphos promotes healthy adrenal function and an optimal response to stress.*

Supplementation with Seriphos:

 Seriphos Contains Phosphorylated Serine & Ethanolamine Phosphate

How Does Seriphos Work?

Seriphos contains phosphorylated serine and ethanolamine phosphate. Evidence suggests that the ingredients in Seriphos can support the stress response by normalizing cortisol levels and reducing an individual’s perceived negative response to stress.*

What the Research Shows:

Phospholipids

Phosphorylated serine and ethanolamine phosphate serve as metabolic building blocks for phospholipids such as phosphatidylserine. Research shows that nutritional supplementation with phosphatidylserine supports healthy cortisol levels, improves adaptability to stress, enhances mood, calms anxiety, and supports cognitive function.*^1-3 In elderly patients with elevated cortisol, phosphatidylserine normalizes the hypothalamic-pituitary-adrenal (HPA) axis response.*⁴ Phosphatidylserine supplementation also improves cortisol levels, diurnal cortisol rhythms, and mood in some elderly patients with depression.*⁵ In chronically-stressed adults, phosphatidylserine blunts elevated cortisol and adrenocorticotropic hormone (ACTH) levels, enhances mood, calms anxiety, and attenuates perceived mental and emotional stress.*^6-9 In healthy young adults, phosphatidylserine supplementation blunts cortisol and ACTH responses to strenuous exercise, reduces post-exercise muscle soreness, and enhances perception of well-being.*^10-12 For more information on the safety and benefits of phospholipids please visit our blog page. 

FDA Qualified Health Claims

The ability of phosphatidylserine to support cognition and interrupt cognitive deterioration has been recognized by the FDA in its approval of the following qualified health claims:

• “Consumption of phosphatidylserine may reduce the risk of dementia in the elderly. Very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of dementia in the elderly. FDA concludes that there is little scientific evidence supporting this claim.”
• “Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. FDA concludes that there is little scientific evidence supporting this claim."

These qualified health claims pertain to dietary supplements containing soy-derived phosphatidylserine. Please note that Seriphos contains phosphorylated serine and not phosphatidylserine.

Summary

Seriphos is formulated with phosphorylated serine and ethanolamine phosphate to reduce occasional anxiety and stress and to support healthy cortisol levels.*

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Phospholipids, including phosphatidylserine and phosphatidylethanolamine, sound like scary toxic chemicals, but every cell in your body requires phospholipids to function. Phospholipids are also present in nearly all food, so you eat them daily too! And - decades of medical research show supplementing with phospholipids could offer several significant health benefits.*

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Thank you for joining us for Part 3 of our exciting blog series! Continue reading to learn about phosphatidylethanolamine and the building blocks your body needs to produce this essential phospholipid.

 

References:

¹ Kidd PM. Phosphatidylserine; membrane nutrient for memory. A clinical and mechanistic assessment. Alt Med Rev. 1996;1(2):70-84.

² Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015;31(6):781-6. doi:10.1016/j.nut.2014.10.014

³ Carter J, Greenwood, M. Phosphatidylserine for the athlete. Strength & Conditioning Journal. 2015;37(1):61-68.

⁴ Nerozzi D, Magnani A, Sforza V, et al. Early cortisol escape phenomenon reversed by phosphatidylserine in elderly normal subjects. Clin Trials J. 1989;26:33-38.

⁵ Komori T. The effects of phosphatidylserine and omega-3 fatty acid-containing supplement on late life depression. Ment Illn. 2015;7(1):5647. doi:10.4081/mi.2015.5647

⁶ Hellhammer J, Fries E, Buss C, et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-26.

⁷ Hellhammer J, Vogt D, Franz N, et al. A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis. 2014;13:121. doi:10.1186/1476-511X-13-121

⁸ Hellhammer J, Hero T, Franz N, et al. Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men. Nutr Res. 2012;32(4):241-50. doi:10.1016/j.nutres.2012.03.003

⁹ Benton D, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-78.

¹⁰ Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992;42(4):385-8.

¹¹ Fahey TD, Pearl MS. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biology of Sport. 1998;15(3):135-144.

¹² Starks MA, Starks SL, Kingsley M, et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr. 2008;5:11. doi:10.1186/1550-2783-5-11