Fura-Mag
Supports healthy cardiovascular, musculoskeletal, endocrine, neurological, and metabolic function.*
Highly Bioavailable Magnesium with Vitamin B6*
Magnesium fumarate is a fully-reacted, organically-bound magnesium salt that offers superior bioavailability.1* Pyridoxine hydrochloride (Vitamin B6) is known to enhance the absorption of magnesium into cells.2*
Magnesium deficiency is a common concern in today's society since stress depletes magnesium, and many people do not consume the recommended daily amount of magnesium from food. Due to the numerous health benefits of adequate magnesium and Vitamin B6 intake, supplementation with Fura-MagTM may be helpful for individuals dealing with high levels of stress and stress-related health concerns.*
Supplementation with Fura-MagTM:
- Supports healthy cardiovascular function*
- Inhibits platelet aggregation & dilates blood vessels*
- Provides nutritional support for muscles & bones*
- Reduces muscle spasm & soreness*
- Supports healthy bone density*
- Supports normal vitamin D synthesis & activity*
- Speeds recovery after training*
- Supports normal energy metabolism*
- Supports cognitive function*
- Enhances positive mood*
- Improves adaptability to stress*
- Supports normal blood sugar levels*
- Improves insulin function*
How Does Fura-MagTM Work?
Fura-MagTM is formulated with bioavailable magnesium and vitamin B6 for cardiovascular, musculoskeletal, endocrine, neurological, and metabolic support.*
What the research shows:
Magnesium plays many crucial roles in human physiology. Magnesium is involved in hundreds of enzymatic processes in the body that, in turn, influence the function of numerous body systems and metabolic pathways.
Magnesium supports cardiovascular function. It acts as a natural calcium channel blocker and a cofactor for maintaining cell membrane potential, which is crucial for establishing a steady, regular heartbeat.3,4 Magnesium decreases the vascular and endothelial inflammation involved in atherosclerosis and hypertension.5,6 Low magnesium levels induce an inflammatory state in general, which can have detrimental effects on the body.7
Magnesium influences electrolyte levels inside cells by moderating cell membrane transport and cell-substrate adherence. Acting as a counterbalance to calcium, magnesium encourages muscle relaxation by increasing the reuptake of calcium after muscle contraction.8
Magnesium is also a structural nutrient that maintains the health of bones and teeth. Around 60% of magnesium is stored in bone, with most of the remainder in the skeletal muscle and soft tissues. Depleted magnesium levels and the resulting chronic inflammation are known to increase bone loss, whereas magnesium supplementation has been shown to reduce bone loss.9
Studies also show that stress and magnesium10 are linked: increased stress causes urinary loss of magnesium, and elevated catecholamine concentrations have been shown to lower serum magnesium levels.11 In addition, low magnesium levels can worsen the overall cumulative negative effects of the stress response.12 Magnesium supplementation has been shown to lower cortisol levels while improving swimming and running times in competitive triathletes.13 In situations of chronic stress, increased intake of magnesium may be required to maintain adequate magnesium stores.
Magnesium is also necessary for normal neurological function and neurotransmitter release.14 The links between magnesium status and mental health are well-documented by research. Magnesium-deficient diets in animals are associated with depressive and anxiogenic behaviors.15 Low magnesium status also appears to correlate with depression in humans, although more research is needed to fully confirm the link.16 Increased magnesium intake also has been shown to decrease neuronal overexcitation and improve reasoning coherence.17
Blood sugar and insulin problems also correlate with low magnesium levels. Research shows that diabetic patients are commonly deficient in magnesium,18 and low magnesium levels are associated with insulin resistance.19,20 Diabetes is more common in people with low magnesium intake, and complications of diabetes are more prevalent in diabetics with low magnesium levels.20 Magnesium supplementation may help to stabilize blood sugar, restore insulin sensitivity, and normalize insulin-induced changes in cortisol output.21,22
An animal study confirms supplementation with magnesium fumarate significantly reduces levels of norepinephrine and cortisol, which are stress hormones. The study also suggests magnesium fumarate supplementation may decrease cholesterol, blood sugar, and lactic acid levels.23
Vitamin B6 appears to facilitate the absorption of magnesium into cells.2 Some conditions, including severe stress and PMS, respond better to a combination of magnesium and vitamin B6 than to either supplement alone.24,25 Vitamin B6 has numerous activities in the body, helping in over 100 enzymatic reactions. Research has shown that vitamin B6 may reduce the incidence of heart disease.26 In addition, it appears that B6 has anti-inflammatory benefits,27 which could explain why vitamin B6 improves symptoms in those with carpal tunnel syndrome.28
References:
1 Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Ther. 2001;8(5):345-357. doi:10.1097/00045391-200109000-00008
2 Abraham GE, Schwartz UD, Lubran MM. Effect of vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal women. Ann Clin Lab Sci. 1981;11(4):333-336.
3 Romani AM. Magnesium in health and disease. Met Ions Life Sci. 2013;13:49-79. doi:10.1007/978-94-007-7500-8_3
4 Ross AC, et al., eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams & Wilkins; 2012:159-75.
5 Rayssiguier Y, Libako P, Nowacki W, et al. Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation. Magnes Res. 2010;23(2):73-80. doi:10.1684/mrh.2010.0208
6 Altura BM, Shah NC, Shah GJ, et al. Magnesium deficiency upregulates sphingomyelinases in cardiovascular tissues and cells: cross-talk among proto-oncogenes, Mg(2+), NF-κB and ceramide and their potential relationships to resistant hypertension, atherogenesis and cardiac failure. Int J Clin Exp Med. 2013;6(10):861-879.
7 Mazur A, Maier JA, Rock E, et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys. 2007;458(1):48-56. doi:10.1016/j.abb.2006.03.031
8 Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24(2):47-66.
9 Aydin H, Deyneli O, Yavuz D, et al. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res. 2010;133(2):136-143. doi:10.1007/s12011-009-8416-8
10 Mocci F, Canalis P, Tomasi PA, et al. The effect of noise on serum and urinary magnesium and catecholamines in humans. Occup Med (Lond). 2001;51(1):56-61. doi:10.1093/occmed/51.1.56
11 Whyte KF, Addis GJ, Whitesmith R, et al. Adrenergic control of plasma magnesium in man. Clin Sci (Lond). 1987;72(1):135-138. doi:10.1042/cs0720135
12 Seelig MS. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review). J Am Coll Nutr. 1994;13(5):429-446. doi:10.1080/07315724.1994.10718432
13 Golf SW, Bender S, Grüttner J. On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther. 1998;12 Suppl 2:197-202. doi:10.1023/a:1007708918683
14 Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(Suppl 1):i3-i14. doi:10.1093/ndtplus/sfr163
15 Singewald N, Sinner C, Hetzenauer A, et al. Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract. Neuropharmacology. 2004;47(8):1189-1197. doi:10.1016/j.neuropharm.2004.08.010
16 Cheungpasitporn W, Thongprayoon C, Mao MA, et al. Hypomagnesaemia linked to depression: a systematic review and meta-analysis. Intern Med J. 2015;45(4):436-440. doi:10.1111/imj.12682
17 Long S, Romani AM. Role of Cellular Magnesium in Human Diseases. Austin J Nutr Food Sci. 2014;2(10):1051.ong S, Romani AM. Austin J Nutr Food Sci. 2014;2(10):1051.
18 Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199-8226. doi:10.3390/nu7095388
19 Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012;70(3):153-164. doi:10.1111/j.1753-4887.2011.00465.x
20 Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-1003. doi:10.4103/2230-8210.103020
21 Heer M, Egert S. Nutrients other than carbohydrates: their effects on glucose homeostasis in humans. Diabetes Metab Res Rev. 2015;31(1):14-35. doi:10.1002/dmrr.2533
22 Rotter I, Kosik-Bogacka D, Dołęgowska B, et al. Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older men. Magnes Res. 2015;28(3):99-107. doi:10.1684/mrh.2015.0391
23 Otten W, Bergerhoff A, Berrer M, Goldberg M, Eichinger HM. Effects of a magnesium fumarate supplementation on catecholamines, cortisol and blood metabolites in swine. In: Proceedings of the 39th International Congress of Meat Science and Technology. Calgary, Alberta; 1993:S2P16.WP. http://icomst-proceedings.helsinki.fi/papers/1993_02_16.pdf. Accessed December 7, 2022..
24 Fathizadeh N, Ebrahimi E, Valiani M, et al. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):401-405.
25 Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. doi:10.1371/journal.pone.0208454
26 Rimm EB. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Bibl Nutr Dieta. 2001;(55):42-45. doi:10.1159/000059460
27 Friso S, Girelli D, Martinelli N, et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 2004;79(6):992-998. doi:10.1093/ajcn/79.6.992
28 Talebi M, Andalib S, Bakhti S, et al. Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome. Adv Pharm Bull. 2013;3(2):283-288. doi:10.5681/apb.2013.046