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Adapt


Vitamin, Mineral & Herbal Adrenal Support*

Supports healthy adrenal output and function*

Adapt™ provides targeted B-vitamins, including high-dose pantothenic acid and biotin, bioavailable minerals, and organic herbal extracts to support healthy adrenal function and a balanced response to stress.*

High-dose pantothenic acid has been shown to increase cortisol production and improve the acute stress response in animal studies. Zinc and the organic herbal extracts in Adapt™ have been shown to help modulate cortisol release in response to stress. Biotin may also support normal blood sugar levels, which can be an important factor in balancing cortisol levels.*

Adapt™ supports a healthy and balanced response to stress.*

Adapt Main Label Data Sheet

Supplementation with Adapt™:

  • Supports Healthy Cortisol Production*
  • Improves Adaptability to Stress*
  • Helps maintain healthy blood sugar regulation*
  • Calms occasional anxiety*
  • Protects neurons from stress-induced damage*

      Adapt™ Contains Pantothenic Acid, Vitamin B6, Biotin, Zinc, Copper, Ashwagandha, Rosemary, and Citrus Bioflavonoids.

      What the Research Shows:

      Pantothenic Acid (Vitamin B5)

      Pantothenic acid deficiency is associated with adrenal fatigue, and; in animal studies, pantothenic acid has been shown to raise cortisol levels.1-3 Pantothenic acid also appears to improve stress resiliency, acting as a modulating agent for adrenal function.3 Pantothenic acid is a precursor for acetyl coenzyme A (acetyl CoA), a compound essential for the production of corticosteroid hormones.

      Vitamin B6

      Vitamin B6 (pyridoxine hcl) is a cofactor for numerous enzymatic processes throughout the body. Recent evidence supports the role of vitamin B6 in the cellular stress response for protection from free radicals and other environmental stressors.4 In addition, vitamin B6 is a necessary cofactor for the metabolism of several important neurotransmitters and neurotransmitter precursors associated with stress, most notably gamma aminobutyric acid (GABA), 5 hydroxytryptophan (5-HTP), serotonin, and dopamine.5,6

      Zinc

      Zinc deficiency can impair a healthy stress response, and zinc appears to moderate cortisol release with stress.7,8 In humans, optimal zinc levels can help stabilize serum cortisol levels postoperatively, preventing a sharp increase in cortisol.9 Overall, proper maintenance of zinc status appears to be important for healthy adrenal function. Copper is included in the formula to balance the zinc.

      Biotin

      A study in fruit flies demonstrated increased life span and improved stress resiliency with biotin supplementation.10 Some human studies have also shown significant improvement in blood sugar control since biotin is involved in the regulation of genes involved in glucose metabolism.11

      Ashwagandha (Withania somnifera)

      An herbal adaptogen with a long history of use in Ayurvedic medicine, Ashwagandha is one of the more relaxing adrenal restoratives.12 The withanolides in Ashwagandha are sterol compounds considered to be responsible for the adaptogenic and glucocorticoid-like effects.6 In individuals under chronic stress, the stress response improved, and serum cortisol was reduced when subjects were given an Ashwagandha extract.13 Animal studies using Ashwagandha have noted improvements in cortisol output, blood sugar control, and depression- and anxiety-associated behavior triggered by social isolation.6 In addition, Ashwagandha has been shown in animal studies to raise active thyroid hormone levels.14

      Rosemary (Rosmarinus officinalis)

      A common culinary herb, rosemary is also employed in traditional medicine for its strong and natural antiseptic, anti-inflammatory, and antioxidant properties.15,16 Rosemary is a rich source of bioactive constituents, including flavonoids and phenolic acids, with rosmarinic acid and carnosic acid being two of the more well-researched constituents.16,17 Extracts of rosemary show promising neuroprotective effects in models of neuroinflammation and neurodegeneration, as well as in chemical-induced neurotoxicity and oxidative stress.16,18

      Citrus Bioflavonoids

      Rutin, a common citrus bioflavonoid, can help balance steroid hormones and lower elevated cortisol.19 Naringenin, another citrus bioflavonoid, may improve insulin sensitivity and help balance blood sugar.20

      Adapt Supplement Facts and Cautions

      References:

      1 Gominak SC. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity. Med Hypotheses. 2016;94:103-107. doi:10.1016/j.mehy.2016.07.007

      2 Jaroenporn S, Yamamoto T, Itabashi A, et al. Effects of pantothenic acid supplementation on adrenal steroid secretion from male ratsBiol Pharm Bull. 2008;31(6):1205-1208. doi:10.1248/bpb.31.1205

      3 Dumm M, Laken B, Ralli E. Factors influencing adrenal weight and adrenal cholesterol in rats following stressJ Nutr. 1955;56(4):517-531. doi:10.1093/jn/56.4.517

      4 Mooney S, Leuendorf JE, Hendrickson C, et al. Vitamin B6: a long known compound of surprising complexityMolecules. 2009;14(1):329-351. doi:10.3390/molecules14010329

      5 McCarty M. High-dose pyridoxine as an 'anti-stress' strategyMed Hypotheses. 2000;54(5):803-807. doi:10.1054/mehy.1999.0955

      6 Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleepAltern Med Rev. 2009;14(2):114-140.

      Chen WQ, Cheng YY, Zhao XL, et al. Effects of zinc on the induction of metallothionein isoforms in hippocampus in stress ratsExp Biol Med (Maywood). 2006;231(9):1564-1568. doi:10.1177/153537020623100917

      8 Brandão-Neto J, de Mendonça B, Shuhama T, et al. Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary reportBiol Trace Elem Res. 1990;24(1):83-89. doi:10.1007/BF02789143

      9 Faure H, Peyrin JC, Richard MJ, et al. Parenteral supplementation with zinc in surgical patients corrects postoperative serum-zinc dropBiol Trace Elem Res. 1991;30(1):37-45. doi:10.1007/BF02990340

      10 Landenberger A, Kabil H, Harshman LG, et al. Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogasterJ Nutr Biochem. 2004;15(10):591-600. doi:10.1016/j.jnutbio.2004.04.006

      11 McCarty MF, DiNicolantonio JJ. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel). 2021;10(1):3. doi:10.3390/healthcare10010003

      12 Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence [published correction appears in CNS Drugs. 2013 Aug;27(8):675. Dosage error in article text]. CNS Drugs. 2013;27(4):301-319. doi:10.1007/s40263-013-0059-9.

      13 Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adultsIndian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

      14 Hosny EN, El-Gizawy MM, Sawie HG, et al. Neuroprotective Effect of Ashwagandha Extract against the Neurochemical Changes Induced in Rat Model of HypothyroidismJ Diet Suppl. 2021;18(1):72-91. doi:10.1080/19390211.2020.1713959

      15 Posadas SJ, Caz V, Largo C, et al. Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged ratsExp Gerontol. 2009;44(6-7):383-389. doi:10.1016/j.exger.2009.02.015

      16 Nabavi SF, Tenore GC, Daglia M, et al. The cellular protective effects of rosmarinic acid: from bench to bedsideCurr Neurovasc Res. 2015;12(1):98-105. doi:10.2174/1567202612666150109113638

      17 de Oliveira MR. The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic ViewMol Neurobiol. 2016;53(9):6155-6168. doi:10.1007/s12035-015-9519-1

      18 Park SE, Kim S, Sapkota K, et al. Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5YCell Mol Neurobiol. 2010;30(5):759-767. doi:10.1007/s10571-010-9502-3

      19 Schloms L, Smith C, Storbeck KH, et al. Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?Mol Nutr Food Res. 2014;58(3):537-549. doi:10.1002/mnfr.201300463

      20 Assini JM, Mulvihill EE, Burke AC, et al. Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21Endocrinology. 2015;156(6):2087-2102. doi:10.1210/en.2014-2003