Adapt

Vitamin, Mineral & Herbal Adrenal Support*

Supports healthy adrenal output and function*

Adapt™ provides targeted B-vitamins, including high-dose pantothenic acid and biotin, bioavailable minerals, and organic herbal extracts to support healthy adrenal function and a balanced response to stress.*

High-dose pantothenic acid has been shown to increase cortisol production and improve the acute stress response in animal studies. Zinc and the organic herbal extracts in Adapt™ have been shown to help modulate cortisol release in response to stress. Biotin may also support normal blood sugar levels, which can be an important factor in balancing cortisol levels.*

Adapt™ supports a healthy and balanced response to stress.*

Supplementation with Adapt™:

Adapt™ Contains Pantothenic Acid, Vitamin B6, Biotin, Zinc, Copper, Ashwagandha, Rosemary, and Citrus Bioflavonoids.

What the Research Shows:

Pantothenic Acid (Vitamin B5)

Pantothenic acid deficiency is associated with adrenal fatigue, and; in animal studies, pantothenic acid has been shown to raise cortisol levels.^1-3 Pantothenic acid also appears to improve stress resiliency, acting as a modulating agent for adrenal function.³ Pantothenic acid is a precursor for acetyl coenzyme A (acetyl CoA), a compound essential for the production of corticosteroid hormones.

Vitamin B6

Vitamin B6 (pyridoxine hcl) is a cofactor for numerous enzymatic processes throughout the body. Recent evidence supports the role of vitamin B6 in the cellular stress response for protection from free radicals and other environmental stressors.⁴ In addition, vitamin B6 is a necessary cofactor for the metabolism of several important neurotransmitters and neurotransmitter precursors associated with stress, most notably gamma aminobutyric acid (GABA), 5 hydroxytryptophan (5-HTP), serotonin, and dopamine.^5,6

Zinc

Zinc deficiency can impair a healthy stress response, and zinc appears to moderate cortisol release with stress.^7,8 In humans, optimal zinc levels can help stabilize serum cortisol levels postoperatively, preventing a sharp increase in cortisol.⁹ Overall, proper maintenance of zinc status appears to be important for healthy adrenal function. Copper is included in the formula to balance the zinc.

Biotin

A study in fruit flies demonstrated increased life span and improved stress resiliency with biotin supplementation.¹⁰ Some human studies have also shown significant improvement in blood sugar control since biotin is involved in the regulation of genes involved in glucose metabolism.¹¹

Ashwagandha (Withania somnifera)

An herbal adaptogen with a long history of use in Ayurvedic medicine, Ashwagandha is one of the more relaxing adrenal restoratives.¹² The withanolides in Ashwagandha are sterol compounds considered to be responsible for the adaptogenic and glucocorticoid-like effects.⁶ In individuals under chronic stress, the stress response improved, and serum cortisol was reduced when subjects were given an Ashwagandha extract.¹³ Animal studies using Ashwagandha have noted improvements in cortisol output, blood sugar control, and depression- and anxiety-associated behavior triggered by social isolation.⁶ In addition, Ashwagandha has been shown in animal studies to raise active thyroid hormone levels.¹⁴

Rosemary (Rosmarinus officinalis)

A common culinary herb, rosemary is also employed in traditional medicine for its strong and natural antiseptic, anti-inflammatory, and antioxidant properties.^15,16 Rosemary is a rich source of bioactive constituents, including flavonoids and phenolic acids, with rosmarinic acid and carnosic acid being two of the more well-researched constituents.^16,17 Extracts of rosemary show promising neuroprotective effects in models of neuroinflammation and neurodegeneration, as well as in chemical-induced neurotoxicity and oxidative stress.^16,18

Citrus Bioflavonoids

Rutin, a common citrus bioflavonoid, can help balance steroid hormones and lower elevated cortisol.¹⁹ Naringenin, another citrus bioflavonoid, may improve insulin sensitivity and help balance blood sugar.²⁰

References:

¹ Gominak SC. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity. Med Hypotheses. 2016;94:103-107. doi:10.1016/j.mehy.2016.07.007

² Jaroenporn S, Yamamoto T, Itabashi A, et al. Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. Biol Pharm Bull. 2008;31(6):1205-1208. doi:10.1248/bpb.31.1205

³ Dumm M, Laken B, Ralli E. Factors influencing adrenal weight and adrenal cholesterol in rats following stress. J Nutr. 1955;56(4):517-531. doi:10.1093/jn/56.4.517

⁴ Mooney S, Leuendorf JE, Hendrickson C, et al. Vitamin B6: a long known compound of surprising complexity. Molecules. 2009;14(1):329-351. doi:10.3390/molecules14010329

⁵ McCarty M. High-dose pyridoxine as an 'anti-stress' strategy. Med Hypotheses. 2000;54(5):803-807. doi:10.1054/mehy.1999.0955

⁶ Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140.

⁷ Chen WQ, Cheng YY, Zhao XL, et al. Effects of zinc on the induction of metallothionein isoforms in hippocampus in stress rats. Exp Biol Med (Maywood). 2006;231(9):1564-1568. doi:10.1177/153537020623100917

⁸ Brandão-Neto J, de Mendonça B, Shuhama T, et al. Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report. Biol Trace Elem Res. 1990;24(1):83-89. doi:10.1007/BF02789143

⁹ Faure H, Peyrin JC, Richard MJ, et al. Parenteral supplementation with zinc in surgical patients corrects postoperative serum-zinc drop. Biol Trace Elem Res. 1991;30(1):37-45. doi:10.1007/BF02990340

¹⁰ Landenberger A, Kabil H, Harshman LG, et al. Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster. J Nutr Biochem. 2004;15(10):591-600. doi:10.1016/j.jnutbio.2004.04.006

¹¹ McCarty MF, DiNicolantonio JJ. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel). 2021;10(1):3. doi:10.3390/healthcare10010003

¹² Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence [published correction appears in CNS Drugs. 2013 Aug;27(8):675. Dosage error in article text]. CNS Drugs. 2013;27(4):301-319. doi:10.1007/s40263-013-0059-9.

¹³ Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

¹⁴ Hosny EN, El-Gizawy MM, Sawie HG, et al. Neuroprotective Effect of Ashwagandha Extract against the Neurochemical Changes Induced in Rat Model of Hypothyroidism. J Diet Suppl. 2021;18(1):72-91. doi:10.1080/19390211.2020.1713959

¹⁵ Posadas SJ, Caz V, Largo C, et al. Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats. Exp Gerontol. 2009;44(6-7):383-389. doi:10.1016/j.exger.2009.02.015

¹⁶ Nabavi SF, Tenore GC, Daglia M, et al. The cellular protective effects of rosmarinic acid: from bench to bedside. Curr Neurovasc Res. 2015;12(1):98-105. doi:10.2174/1567202612666150109113638

¹⁷ de Oliveira MR. The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View. Mol Neurobiol. 2016;53(9):6155-6168. doi:10.1007/s12035-015-9519-1

¹⁸ Park SE, Kim S, Sapkota K, et al. Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y. Cell Mol Neurobiol. 2010;30(5):759-767. doi:10.1007/s10571-010-9502-3

¹⁹ Schloms L, Smith C, Storbeck KH, et al. Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?. Mol Nutr Food Res. 2014;58(3):537-549. doi:10.1002/mnfr.201300463

²⁰ Assini JM, Mulvihill EE, Burke AC, et al. Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. Endocrinology. 2015;156(6):2087-2102. doi:10.1210/en.2014-2003