Flavo PlexC

Vitamin C with Pure Flavonoids & Plant Extracts

A potent blend of vitamin C, plant extracts, and bioflavonoids to encourage a healthy immune response and improve antioxidant levels.

   Vitamin C  •  Ashwagandha  •  Grape Seed Extract  •  Hesperidin

The immune system is constantly challenged through exposure to allergens, microbes, and other invaders. Normally the body can optimize its immune response; however, in some situations, the response may be sluggish or inappropriate and may require modulation to prevent immune dysregulation.

How does Flavo PlexC™ work:

Supplementation with Flavo PlexC™:

• Supplies antioxidants*
• Protects tissues from free radical damage during times of oxidative stress*
• Decreases histamine release and concentration*
• Helps stabilize blood vessel integrity and permeability*
• Stimulates immune system activity*
• Improves response to stress*
• Supports detoxification pathways*
• Provides cofactors and coenzymes essential for neurotransmitter synthesis, optimal cognitive function, and a healthy nervous system*

What the Research and Clinical Use Shows:

Vitamin C 

Vitamin C is a versatile nutrient found in plant foods, especially citrus fruits and leafy greens, as it provides resistance to the oxidative stresses created during photosynthesis. This essential water-soluble vitamin must be obtained from the diet as humans (and a few other animals like guinea pigs and fruit bats) lack the enzyme to synthesize it. Vitamin C is required for the healthy structure and function of the body, and vitamin C status may even be linked to rates of survival.

Several large-scale prospective cohort studies have supported a correlation between vitamin C and a lower risk of mortality and cardiovascular diseases.^1,2 Vitamin C is required in the formation of bones, muscles, and cartilage.³ Additionally, vitamin C is an important antioxidant and modulator of the immune system and is used to make neurotransmitters.³ It is considered an “immunostimulant” because it encourages immune cell activity against pathogens.³* Vitamin C also inhibits histamine secretion by mast cells and lowers blood histamine levels, thereby improving allergy symptoms.⁴*

Hesperidin

Flavonoids (bioflavonoids) are polyphenolic plant chemicals found throughout the plant kingdom. Flavonoids provide a variety of physiological benefits.* It is believed they work synergistically with vitamin C as antioxidants and anti-allergens. Hesperidin is a flavonoid found in citrus fruits. Hesperidin is beneficial to both the cardiovascular and neurological systems. In animal models, hesperidin use reduced the incidence of strokes and neurological diseases.⁵

Clinically, hesperidin reduces diastolic blood pressure after four weeks of supplementation.⁶ In a separate clinical trial of participants with metabolic syndrome, an improvement in endothelial function was seen following hesperidin administration, possibly due to an increase in nitric oxide production.⁷ In the same trial, hesperidin administration reduced circulating levels of inflammatory biomarkers and pro-atherogenic compounds.⁷

Ashwagandha (Withania somnifera) root extract

Ashwagandha, is an Ayurvedic herb used as an adaptogen, an antioxidant, and a natural anti-inflammatory remedy that assists the body in performing its best during acute and chronic stress.⁸* In-vitro studies have proven Ashwagandha’s activity against cancer cells. Withanolides, active constituents in Ashwagandha extracts, are considered to be responsible for the adaptogenic and glucocorticoid-like effects.⁹ Clinically, Ashwagandha administered with cow’s milk was shown to increase the activation of lymphocytes, thereby increasing immune system activity.⁸* As an adaptogen, this herb improves outcomes from perceived stress clinically.¹⁰*

Grape Seed Extract (VITIS VINIFERA)

Red grape seed extract is rich in bioflavonoids known as proanthocyanidins, which are effective antioxidant, anti-inflammatory, and blood vessel stabilizing compounds.¹¹* In a study of 16 women, a standardized dose of grape seed extract decreased venous stasis edema (swelling) in the lower legs after sitting for several hours.¹¹

References:

¹ McRae MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. J Chiropr Med. 2008;7(2):48-58. doi:10.1016/j.jcme.2008.01.002

² Pocobelli G, Peters U, Kristal AR, et al. Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol. 2009;170(4):472-483. doi:10.1093/aje/kwp167

³ Sorice A, Guerriero E, Capone F, et al. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Rev Med Chem. 2014;14(5):444-452. doi:10.2174/1389557514666140428112602

⁴ Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev. 2006;11(3):196-207.

⁵ Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017;57(3):613-631. doi:10.1080/10408398.2014.906382

⁶ Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr. 2011;93(1):73-80. doi:10.3945/ajcn.110.004945

⁷ Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011;96(5):E782-E792. doi:10.1210/jc.2010-2879

⁸ Mikolai J, Erlandsen A, Murison A, et al. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. J Altern Complement Med. 2009;15(4):423-430. doi:10.1089/acm.2008.0215

⁹ Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140.

¹⁰ Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

¹¹ Sano A, Tokutake S, Seo A. Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. J Sci Food Agric. 2013;93(3):457-462. doi:10.1002/jsfa.5773