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Seriphos


Phosphorylated Serine & Synergistic Nutrients Adaptogen and Adrenal Support*

Stress is a common feature of everyday life that can raise cortisol levels and lead to significant health problems. Seriphos was developed to aid in lowering cortisol when cortisol levels are elevated due to acute and chronic stress.*

Seriphos contains key nutrients for stress resiliency.* This original and unique formulation provides phosphorylated serine along with a synergistic blend of magnesium and calcium ethanolamine phosphates to promote a more balanced and healthy stress response.* Phosphorylated serine and ethanolamine phosphate serve as metabolic building blocks for the synthesis of phosphatidylserine and phosphatidylethanolamine, cell membrane phospholipids that regulate key aspects of cellular function.

The synergistic formulation of phosphorylated serine, ethanolamine phosphate, and mineral salts in Seriphos promotes healthy adrenal function and an optimal response to stress.*

Seriphos Main Label Data Sheet

Supplementation with Seriphos:

  • Supports healthy cortisol levels*
  • Improves adaptability to stress*
  • Enhances positive mood*
  • Calms occasional anxiety*
  • Supports cognitive function*

 Seriphos Contains Phosphorylated Serine & Ethanolamine

How Does Seriphos Work?

Seriphos contains phosphorylated serine along with ethanolamine phosphate, magnesium, calcium, and phosphorus. Evidence suggests that the ingredients in Seriphos support the stress response by normalizing cortisol levels and reducing an individual’s perceived negative response to stress.*

What the Research Shows:

Phospholipids

Phosphorylated serine and ethanolamine phosphate serve as metabolic building blocks for phospholipids such as phosphatidylserine. Research shows that nutritional supplementation with phosphatidylserine supports healthy cortisol levels, improves adaptability to stress, enhances mood, calms anxiety, and supports cognitive function.*1-3 In elderly patients with elevated cortisol, phosphatidylserine normalizes the hypothalamic-pituitary-adrenal (HPA) axis response.*4 Phosphatidylserine supplementation also improves cortisol levels, diurnal cortisol rhythms, and mood in some elderly patients with depression.*5 In chronically-stressed adults, phosphatidylserine blunts elevated cortisol and adrenocorticotropic hormone (ACTH) levels, enhances mood, calms anxiety, and attenuates perceived mental and emotional stress.*6-9 In healthy young adults, phosphatidylserine supplementation blunts cortisol and ACTH responses to strenuous exercise, reduces post-exercise muscle soreness, and enhances perception of well-being.*10-12

Magnesium

Supplemental magnesium has been shown to lower cortisol and insulin levels, while improving swimming and running times in competitive triathletes.*13 Magnesium appears to be depleted by high levels of circulating catecholamines during stress.*14 In addition, low magnesium levels can worsen the overall cumulative negative effects of the stress response.15 Magnesium levels are often low in diabetics, and supplemental magnesium can help restore insulin sensitivity and stabilize blood sugar levels.*16

Calcium

Stress also may be worsened by depression and anxiety. Low calcium levels are associated with mood symptoms, including anxiety and depression.*17 Researchers have hypothesized that premenstrual syndrome is a cyclic manifestation of low calcium levels. Supplemental calcium has been shown to alleviate PMS symptoms and may improve mood symptoms in individuals with marginal calcium status.*18

FDA Qualified Health Claims

The ability of phosphatidylserine to support cognition and interrupt cognitive deterioration has been recognized by the FDA in its approval of the following qualified health claims:

  • ‚ÄúConsumption of phosphatidylserine may reduce the risk of dementia in the elderly. Very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of dementia in the elderly. FDA concludes that there is little scientific evidence supporting this claim.‚ÄĚ
  • ‚ÄúConsumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. FDA concludes that there is little scientific evidence supporting this claim."

These qualified health claims pertain to dietary supplements containing soy-derived phosphatidylserine. Please note that Seriphos contains phosphorylated serine and not phosphatidylserine.

Summary

Seriphos is formulated with phosphorylated serine and synergistic nutrients to reduce occasional anxiety and stress and to support healthy cortisol levels.*

Seriphos Supplement Facts -InterPlexus Data Sheet

References:

1 Kidd PM. Alt Med Rev. 1996;1(2):70-84.

2 Glade MJ, Smith K. Nutrition. 2015;31(6):781-6. doi: 10.1016/j.nut.2014.10.014.

3 Carter J, Greenwood, M. Strength & Conditioning Journal. 2015;37(1):61-68.

4 Nerozzi D, et al. Clin Trials J. 1989;26:33-38.

5 Komori T. Ment Illn. 2015;7(1):5647. doi: 10.4081/mi.2015.5647.

6 Hellhammer J, et al. Stress. 2004;7(2):119-26.

7 Hellhammer J, et al. Lipids Health Dis. 2014;13:121. doi: 10.1186/1476-511X-13-121.

8 Hellhammer J, et al. Nutr Res. 2012;32(4):241-50. doi: 10.1016/j.nutres.2012.03.003.

9 Benton D, et al. Nutr Neurosci. 2001;4(3):169-78.

10 Monteleone P, et al. Eur J Clin Pharmacol. 1992;42(4):385-8.

11 Fahey TD, Pearl MS. Biology of Sport. 1998;15(3):135-144.

12 Starks MA, et al. J Int Soc Sports Nutr. 2008;5:11. doi: 10.1186/1550-2783-5-11.

13 Golf SW, et al. Cardiovasc Drugs Ther. 1998;12 Suppl 2:197-202.

14 Whyte KF, et al. Clin Sci (Lond). 1987;72(1):135-8.

15 Seelig MS. J Am Coll Nutr. 1994;13(5):429-46.

16 Rotter I, et al. Magnes Res. 2015;28(3):99-107. doi: 10.1684/mrh.2015.0391.

17 Lawlor BA. J Clin Psychiatry. 1988;49(8):317-8.

18 Thys-Jacobs S. J Am Coll Nutr. 2000;19(2):220-7.