IPX-Booster Super Strength
Postbiotic supplement featuring a unique array of bioactive metabolites.
Formulated to support a healthy gut microbiome, optimal metabolic health, and balanced immune function*
IPX-Booster Super Strength (SS) is a postbiotic extract with a unique array of over 400 biologically active postbiotic metabolites, including short-chain fatty acids, proteins, peptides, polyphenols, vitamins, minerals, amino acids, nucleic acids, polysaccharides, and other beneficial compounds.*
The production of IPX-Booster SS begins with organic non-GMO soybeans and 25 carefully selected strains of lactic acid-producing bacteria, including Lactobacillus and Bifidobacterium species. IPX-Booster SS is fermented for two years, and the final extract contains numerous beneficial bacterial cultures and a unique array of postbiotic nutrients.*
IPX-Booster SS is a nourishing blend of postbiotic nutrients that may be taken daily to support well-being.*
Supplementation with IPX-Booster Super Strength:
- Helps maintain a healthy gut microbiome*
- Balances the function of the immune system*
- Supports the structural integrity of the lining of the GI tract*
- Enhances adiponectin production to support healthy insulin, glucose, and cholesterol levels*
- Provides anti-inflammatory benefits*
- Stimulates the production of protective sIgA antibodies*
- Supports a healthy blood pressure level*
- Promotes optimal cellular health and functionality*
- Supports healthy skin and hair growth*
What Are Post Biotics?
Postbiotics, also known as biogenics, have been part of a healthy diet for millennia, and modern research techniques are beginning to elucidate the many underlying mechanisms by which postbiotics manifest beneficial effects. Postbiotics are inactivated probiotic bacterial cells and cell components, along with numerous metabolic byproducts made during the fermentation process, which may exert a beneficial effect on the host, either directly or indirectly.1
Fermentation is one of the oldest forms of processing and preserving foods, and we know from research that fermentation can improve the nutritional and functional properties of foods. Fermentation has been widely utilized to increase the bioavailability of nutrients, metabolize “anti-nutrients,” reduce allergenic potential, and produce unique health-promoting substances.2
Probiotic-generated postbiotic nutrients can regulate and maintain the body’s healthy intestinal microbiome while initiating thousands of chemical reactions in cells throughout the body to influence many vital functions. According to current data, postbiotics have pleiotropic effects, including immunomodulatory, anti-inflammatory, antioxidant, and anti-cancer properties.3-5
Short-chain fatty acids (SCFAs) are one type of postbiotic known to decrease inflammation, modulate the gut microbiome, and impact well-being. Research reveals that SCFAs enhance the clearance of Klebsiella pneumoniae and Proteus mirabilis from the intestinal tract and represent a potential therapeutic approach to antibiotic-resistant pathogens.6
Research also confirms that dysbiosis in patients with inflammatory bowel disease (IBD) is associated with impaired SCFA-fermentative pathways, whereas robust production of SCFAs is associated with a reduced risk of developing IBD.7 SCFAs are known to exhibit modulating effects on the cells of the immune system, including regulatory T cells (Tregs), neutrophils, and macrophages.7,8 SCFAs also impact cytokine production and migration, cytolytic activity, and epigenetic expression.7
In the gastrointestinal tract, human and animal trials confirm that supplementation with postbiotics increases the production of protective microbiome-modulating secretory IgA (sIgA) antibodies.8-10 According to several human and animal studies, supplementation with postbiotics also results in increased numbers of circulating Treg cells, improved hepatic function, improved intestinal microbial balance, and longer and healthier microvilli in the duodenum, jejunum, and ileum, which could improve nutrient absorption.11-16
Postbiotics are known to facilitate metabolic benefits beyond the gastrointestinal tract as well.17 One in vitro study concluded that the administration of postbiotics to adipose cells increased adiponectin production by 220%, which may reduce the risk of developing lifestyle-related diseases such as atherosclerosis, diabetes, insulin resistance, and high blood pressure.18,19 Adiponectin is an endocrine factor synthesized and released from adipose tissue that boasts insulin-sensitizing, anti-atherogenic, and anti-inflammatory properties.20
References:
1. Salminen S, Collado MC, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics [published correction appears in Nat Rev Gastroenterol Hepatol. 2021 Jun 15;:] [published correction appears in Nat Rev Gastroenterol Hepatol. 2022 Aug;19(8):551]. Nat Rev Gastroenterol Hepatol. 2021;18(9):649-667. doi:10.1038/s41575-021-00440-6
2. Mukherjee R, Chakraborty R, Dutta A. Role of Fermentation in Improving Nutritional Quality of Soybean Meal - A Review. Asian-Australas J Anim Sci. 2016;29(11):1523-1529. doi:10.5713/ajas.15.0627
3. Żółkiewicz J, Marzec A, Ruszczyński M, et al. Postbiotics-A Step Beyond Pre- and Probiotics. Nutrients. 2020;12(8):2189. doi:10.3390/nu12082189
4. Mayorgas A, Dotti I, Salas A. Microbial Metabolites, Postbiotics, and Intestinal Epithelial Function. Mol Nutr Food Res. 2021;65(5):e2000188. doi:10.1002/mnfr.202000188
5. Piqué N, Berlanga M, Miñana-Galbis D. Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview. Int J Mol Sci. 2019;20(10):2534. doi:10.3390/ijms20102534
6. Sorbara MT, Dubin K, Littmann ER, et al. Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification. J Exp Med. 2019;216(1):84-98. doi:10.1084/jem.20181639
7. Russo E, Giudici F, Fiorindi C, et al. Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease. Front Immunol. 2019;10:2754. doi:10.3389/fimmu.2019.02754
8. Murata Y. Approach to Infection – Immune effects of canine intestinal flora and biogenics. Journal of Modern Veterinary Medicine. 2021;195:27-32. Article in Japanese.
9. Béghin L, Tims S, Roelofs M, et al. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants. Clin Nutr. 2021;40(3):778-787. doi:10.1016/j.clnu.2020.07.024
10. Dunand E, Burns P, Binetti A, et al. Postbiotics produced at laboratory and industrial level as potential functional food ingredients with the capacity to protect mice against Salmonella infection. J Appl Microbiol. 2019;127(1):219-229. doi:10.1111/jam.14276
11. Hayasaka J, Nunomura Y, Omura M, et al. Immunomodulatory effects of lactobacillus biogenic administration in dogs. Japanese Journal of Veterinary Research. 2021;69(3):175-82. doi:10.14943/jjvr.69.3.175
12. Effect of AmitA on serum levels of GOT, GPT, and BUN in a rat model of hepatic dysfunction. Laboratory Animal Research Center, RIKEN. Abstract in Japanese.
13. HRK Bio-tech. The effect of AmitA on modifying gut microbiota in a Chinese cohort. Hcode Research. 2017 Aug; Shenzhen, China.
14. Beneficial effects on intestinal flora by AmitA. A pilot clinical trial, n=5. Abstract in Japanese.
15. The comparison of duodenum microvillus of mice taking 1% AmitA PURE vs. controls. Abstract in Japanese.
16. Humam AM, Loh TC, Foo HL, et al. Effects of Feeding Different Postbiotics Produced by Lactobacillus plantarum on Growth Performance, Carcass Yield, Intestinal Morphology, Gut Microbiota Composition, Immune Status, and Growth Gene Expression in Broilers under Heat Stress. Animals (Basel). 2019;9(9):644. doi:10.3390/ani9090644
17. Liu Q, Liu Y, Li F, et al. Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. J Nutr Biochem. 2020;75:108256. doi:10.1016/j.jnutbio.2019.108256
18. Preadipocytes cultured with AmitA PURE generate 220% increased secretion of adiponectin compared to controls. Japan Society of Nutrition and Food Science. 2007(5). Abstract in Japanese.
19. Al-Mansoori L, Al-Jaber H, Prince MS, et al. Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance. Inflammation. 2022;45(1):31-44. doi:10.1007/s10753-021-01559-z
20. Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017;18(6):1321. doi:10.3390/ijms18061321